Control Theory and Living Therapeutics
Programmed microbes for detection and treatment of infection.
Standardized biological parts within a cell can be systematically rewired to introduce desirable functionalities useful for detection and treatment of infection. We believe that physics-based modeling of internal cell circuitry along with novel control-theoretic tools can be employed to better design, predict and control rewired biomolecular circuits in living cells to treat infection.
Cooperative Feedback Control of Cell Motility
Programmed microbes for self-organized pattern formation.
The ability to rewire biomolecular circuits in living cells provides an engineering approach to explore spatial-temporal self-organization control strategies key to pattern formation and morphogenesis. We believe that physics-based modeling and control theoretic analysis of biomolecular circuitry coupled to cell motility can help design fundamental biomolecular components necessary for robust self-organized pattern formation.
We are constructing a BSL-2 wet lab with microbiological and molecular cloning equipment to run theory-educated experiments.